Leukotrienes and airway inflammation
نویسندگان
چکیده
منابع مشابه
The importance of leukotrienes in airway inflammation in a mouse model of asthma
Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways and increased bronchial hyperreactivity as are observed in human asthma. We employed a model of late-phase allergic pulmonary inflammation in mice to address the role of leukotrienes (LT) in mediating airway eosinophilia and hyperreactivity to methacholine. Allergen intranasal challenge in OVA-sensit...
متن کاملLeukotrienes and the other airway: Celiac disease and asthma collide
ON THE COVER Calderon et al. show that the pancreas has the unique feature of having macrophages from different lineages in distinct anatomical sites. The cover image illustrates that pancreatic islet macrophages derive from defi nitive hematopoiesis (orange), whereas stromal macrophages are of mixed origin, deriving from both defi nitive (orange) and primitive (green) hematopoiesis. Artwork by...
متن کاملTanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma
Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice we...
متن کاملIL-33 and Airway Inflammation
Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-18. Unlike IL-1β and IL-18, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage and may not enhance acquired immune responses through activation of inflammasome. ST2, a IL-33 receptor component, is preferentially expressed by T-helper type (Th) 2 cell...
متن کاملBronchial biopsies and airway inflammation.
Within the last 10 yrs there has been an explosion of interest in the results of biopsy of the airway lining which, whilst invasive, is safe providing it is performed by an experienced bronchoscopist following the published recommendations [1, 2]. The airway mucosa which is sampled comprises surface epithelium and its supportive subepithelial tissue, often referred to as the lamina propria. The...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2011
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2011.02.005